COVID, AMYLOID, AND INFLAMMATION
Literature collection of the CovAmInf workgroup.
Editors Joshua T. Berryman Abdul Mannan Baig Artemi Bendandi Daniel Bonhenry Mattheos A.G. Koffas
SARS-CoV-2 infection as a cause of neurodegeneration (2024)
Daniel Bonhenry, Mirren Charnley, Jorge Gonçalves, Per Hammarström, Michael T Heneka, Ruth Itzhaki, Jean-Charles Lambert, Misbah Mannan, Abdul Mannan Baig, Jinte Middeldorp, Sofie Nyström, Nicholas P Reynolds, Maria Stefanatou, Joshua T Berryman
http://dx.doi.org/10.1016/s1474-4422(24)00178-9
May 16, 2024 - This paper, authored by attendees at the covaminf workshop, provides a brief summary of what is known about the increased risk of Alzheimer's (and neurodegeneration generally) following SARS-CoV-2 infection.
Anthony Fernández-Castañeda, Peiwen Lu, Anna C. Geraghty, Eric Song, Myoung-Hwa Lee, Jamie Wood, Belgin Yalçın, Kathryn R. Taylor, Selena Dutton, Lehi Acosta-Alvarez, Lijun Ni, Daniel Contreras-Esquivel, Jeff R. Gehlhausen, Jon Klein, Carolina Lucas, Tianyang Mao, Julio Silva, Mario A. Peña-Hernández, Alexandra Tabachnikova, Takehiro Takahashi, Laura Tabacof, Jenna Tosto-Mancuso, Erica Breyman, Amy Kontorovich, Dayna McCarthy, Martha Quezado, Marco Hefti, Daniel Perl, Rebecca Folkerth, David Putrino, Avi Nath, Akiko Iwasaki, Michelle Monje
http://dx.doi.org/10.1101/2022.01.07.475453
Jun 05, 2023 - Survivors of SARS-CoV-2 infection often suffer from “brain-fog”, a general degradation of cognitive abilities. This condition shares similarities with the “chemo brain” symptoms experienced by patients after or during cancer treatment. Mice infected by SARS-CoV-2 in the nasal cavit...
SARS-CoV-2 S1 protein causes brain inflammation by reducing intracerebral acetylcholine production (2023)
Naomi Oka, Kazuya Shimada, Azusa Ishii, Nobuyuki Kobayashi, Kazuhiro Kondo
http://dx.doi.org/10.1016/j.isci.2023.106954
May 31, 2023 - No evidence has been found that the neurological damages or complications following an infection by SARS-CoV-2 can be attributed to the proliferation of the virus itself. Mice inoculated in the nasal cavity by an adenovirus with the S1 segment show olfactory lesions, malaise, depre...
The Two-Way Route between Delirium Disorder and Dementia: Insights from COVID-19 (2022)
Giulia Bommarito, Valentina Garibotto, Giovanni B Frisoni, Frédéric Assal, Patrice H Lalive, Gilles Allali
http://dx.doi.org/10.1159/000530566
May 12, 2023 - Delirium affects mainly attention and awareness, and its onset is usually sudden with a finite duration. Dementia affects mainly memory and cognitive function, with a slow and gradual onset and conditions worsening as time goes on. Delirium appeared to be the most common clinical m...
Altered infective competence of the human gut microbiome in COVID-19 (2023)
Laura de Nies, Valentina Galata, Camille Martin-Gallausiaux, Milena Despotovic, Susheel Bhanu Busi, Chantal J. Snoeck, Lea Delacour, Deepthi Poornima Budagavi, Cédric Christian Laczny, Janine Habier, Paula-Cristina Lupu, Rashi Halder, Joëlle V. Fritz, Taina Marques, Estelle Sandt, Marc Paul O’Sullivan, Soumyabrata Ghosh, Venkata Satagopam, Geeta Acharya, Gloria Aguayo, Wim Ammerlaan, Ariane Assele-Kama, Christelle Bahlawane, Katy Beaumont, Nadia Beaupain, Lucrèce Beckers, Camille Bellora, Fay Betsou, Sandie Boly, Dirk Brenner, Eleftheria Charalambous, Emilie Charpentier, Manuel Counson, Brian De Witt, Olivia Domingues, Claire Dording, Bianca Dragomir, Tessy Fautsch, Jean-Yves Ferrand, Ana Festas Lopes, Joëlle Véronique Fritz, Manon Gantenbein, Laura Georges, Jérôme Graas, Gael Hamot, Anne-Marie Hanff, Maxime Hansen, Lisa Hefele, Estelle Henry, Margaux Henry, Eve Herkenne, Christiane Hilger, Judith Hübschen, Laetitia Huiart, Alexander Hundt, Gilles Iserentant, Stéphanie Kler, Pauline Lambert, Sabine Lehmann, Morgane Lemaire, Andrew Lumley, Monica Marchese, Sophie Mériaux, Maura Minelli, Alessandra Mousel, Maeva Munsch, Mareike Neumann, Magali Perquin, Achilleas Pexaras, Jean-Marc Plesseria, Lucie Remark, Bruno Santos, Aurélie Sausy, Margaux Schmitt, Sneeha Seal, Jean-Yves Servais, Florian Simon, Chantal Snoeck, Kate Sokolowska, Hermann Thien, Johanna Trouet, Jonathan Turner, Michel Vaillant, Daniela Valoura Esteves, Charlène Verschueren, Tania Zamboni, Pinar Alper, Piotr Gawron, Enrico Glaab, Clarissa Gomes, Borja Gomez Ramos, Vyron Gorgogietas, Valentin Groues, Wei Gu, Laurent Heirendt, Ahmed Hemedan, Sascha Herzinger, Anne Kaysen, Jacek Jaroslaw Lebioda, Tainà Marques, François Massart, Christiane Olesky, Venkata P. Satagopam, Claire Pauly, Laure Pauly, Lukas Pavelka, Guilherme Ramos Meyers, Armin Rauschenberger, Basile Rommes, Kirsten Rump, Reinhard Schneider, Valerie Schröder, Amna Skrozic, Lara Stute, Noua Toukourou, Christophe Trefois, Carlos Vega Moreno, Maharshi Vyas, Xinhui Wang, Anja Leist, Annika Lutz, Claus Vögele, Linda Hansen, João Manuel Loureiro, Beatrice Nicolai, Alexandra Schweicher, Femke Wauters, Tamir Abdelrahman, Estelle Coibion, Guillaume Fournier, Marie Leick, Friedrich Mühlschlegel, Marie France Pirard, Nguyen Trung, Philipp Jägi, Henry-Michel Cauchie, Delphine Collart, Leslie Ogorzaly, Christian Penny, Cécile Walczak, Rejko Krüger, Guy Fagherazzi, Markus Ollert, Feng Q. Hefeng, Patrick May, Paul Wilmes
http://www.ncbi.nlm.nih.gov/pubmed/36894986
May 10, 2023 - Post covid gut microbiomes were found to be enriched in pathogen-related genes, associated with rotavirus and beta-herpes virus amongst others. The key phrase in this paper is "infective competence": several gut microbiome species expressed genes associated with more agr...
Mutations in SARS-CoV-2 variant nsp6 enhance type-I interferon antagonism (2023)
Cody J. Bills, Hongjie Xia, John Yun-Chung Chen, Jason Yeung, Birte K. Kalveram, David Walker, Xuping Xie, Pei-Yong Shi
http://dx.doi.org/10.1080/22221751.2023.2209208
May 08, 2023 - The discovery of amyloidogenic protein domains in the SARS-CoV-2 proteome may be a critical insight. Mutations within amyloidogenic regions can enhance immune evasion and promote viral replication. Monitoring of emerging variants, with a focus on these specific regions, can augment...
Viruses and amyloids - a vicious liaison (2023)
Per Hammarström, Sofie Nyström
http://www.ncbi.nlm.nih.gov/pubmed/36998202
May 02, 2023 - A review article linking mutliple threads of the covid/amyloid discussion. Touches in the coagulation/aggregation link, looks at evolutionary driving forces for amyloidogenic viral protein, calls for new policy priorities in drug development.
Javier Jarazo, Eveline Santos da Silva, Enrico Glaab, Danielle Perez-Bercoff, Jens C. Schwamborn
http://dx.doi.org/10.1101/2023.03.20.533485
Apr 30, 2023 - The article investigates the impact of SARS-CoV-2 on the midbrain, with a focus on dopaminergic neurons, which are implicated in Parkinson's disease (PD). Researchers used midbrain organoids as an in vitro model for COVID-19 and assessed the direct effects of the virus on dopaminer...
Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils (2023)
Einav Tayeb-Fligelman, Jeannette T. Bowler, Christen E. Tai, Michael R. Sawaya, Yi Xiao Jiang, Gustavo Garcia, Sarah L. Griner, Xinyi Cheng, Lukasz Salwinski, Liisa Lutter, Paul M. Seidler, Jiahui Lu, Gregory M. Rosenberg, Ke Hou, Romany Abskharon, Hope Pan, Chih-Te Zee, David R. Boyer, Yan Li, Daniel H. Anderson, Kevin A. Murray, Genesis Falcon, Duilio Cascio, Lorena Saelices, Robert Damoiseaux, Vaithilingaraja Arumugaswami, Feng Guo, David S. Eisenberg
http://dx.doi.org/10.1038/s41467-023-37865-3
Apr 26, 2023 - This is a substantial look at amyloid formation of the NCAP protein of SARS-CoV-2. NCAP is an RNA binding protein, so assembly is modified in the presence of (viral) RNA but can also function without RNA. Steric zipper crystal structures are prepared for three hexapeptide segments ...
Prodromal Parkinson disease subtypes — key to understanding heterogeneity (2021)
Daniela Berg, Per Borghammer, Seyed-Mohammad Fereshtehnejad, Sebastian Heinzel, Jacob Horsager, Eva Schaeffer, Ronald B. Postuma
http://dx.doi.org/10.1038/s41582-021-00486-9
Apr 14, 2023 - The prodromal signs of Parkinson's disease (and other synucleinopathies) can present decades before overt CNS manifestions emerge (such as tremor and bradykinesia). These early signs include autonomic dysfunction, gastrointestinal problems and REM sleep behavioral disorder (charact...
Dasom Kong, Ki Hoon Park, Da-Hyun Kim, Nam Gyo Kim, Seung-Eun Lee, Nari Shin, Myung Geun Kook, Young Bong Kim, Kyung-Sun Kang
http://dx.doi.org/10.1038/s41420-022-01288-8
Apr 14, 2023 - SARS-CoV-2 infection in a brain organoid model resulted in microgliosis and the formation of beta amyloid plaques. An increase in phosphorylated tau (degradation resistant) was observed as well.
SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein (2022)
Eduardo A. Albornoz, Alberto A. Amarilla, Naphak Modhiran, Sandra Parker, Xaria X. Li, Danushka K. Wijesundara, Julio Aguado, Adriana Pliego Zamora, Christopher L. D. McMillan, Benjamin Liang, Nias Y. G. Peng, Julian D. J. Sng, Fatema Tuj Saima, Jenny N. Fung, John D. Lee, Devina Paramitha, Rhys Parry, Michael S. Avumegah, Ariel Isaacs, Martin W. Lo, Zaray Miranda-Chacon, Daniella Bradshaw, Constanza Salinas-Rebolledo, Niwanthi W. Rajapakse, Ernst J. Wolvetang, Trent P. Munro, Alejandro Rojas-Fernandez, Paul R. Young, Katryn J. Stacey, Alexander A. Khromykh, Keith J. Chappell, Daniel Watterson, Trent M. Woodruff
http://dx.doi.org/10.1038/s41380-022-01831-0
Apr 10, 2023 - The NLRP3 inflammasome activation leads to the release of pro-inflammatory cytokines and pyroptotic cell death, and is linked to neurodegenerative diseases. Protein aggregates such as alpha-synuclein, amyloid beta, TAR DNA-binding protein-43 and superoxidase-1 act as inducers. The ...
Richard J. Smeyne, Jeffrey B. Eells, Debotri Chatterjee, Matthew Byrne, Shaw M. Akula, Srinivas Sriramula, Dorcas P. O'Rourke, Peter Schmidt
http://dx.doi.org/10.1002/mds.29116
Apr 10, 2023 - This is an animal study using mice. 38 days after infection with SARS-CoV-2 the mice were administered a parkinsonian toxin (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)) and then euthanized after 1 week. Neuroinflammation and loss of dopaminergic neurons within the substant...
Christopher Käufer, Cara S. Schreiber, Anna-Sophia Hartke, Ivo Denden, Stephanie Stanelle-Bertram, Sebastian Beck, Nancy Mounogou Kouassi, Georg Beythien, Kathrin Becker, Tom Schreiner, Berfin Schaumburg, Andreas Beineke, Wolfgang Baumgärtner, Gülsah Gabriel, Franziska Richter
http://dx.doi.org/10.1016/j.ebiom.2022.103999
Apr 10, 2023 - The is an animal study focusing on the lingering effects of SARS-CoV-2 infection in the brains of hamsters. 40 animals were used in total. They assessed the differences between infected animals and negative controls during the symptomatic phase (3 days) and post-infection (14 days)...
Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes (2023)
Taniya Bhardwaj, Kundlik Gadhave, Shivani K. Kapuganti, Prateek Kumar, Zacharias Faidon Brotzakis, Kumar Udit Saumya, Namyashree Nayak, Ankur Kumar, Richa Joshi, Bodhidipra Mukherjee, Aparna Bhardwaj, Krishan Gopal Thakur, Neha Garg, Michele Vendruscolo, Rajanish Giri
http://www.ncbi.nlm.nih.gov/pubmed/36806058
Apr 07, 2023 - Amyloidogenic peptides are abundant in both the SARS-CoV and SARS-CoV-2 proteomes. As an extension of earlier work (Charnley 2022), this study identifies a mechanism by which the virus could trigger amyloidosis. The authors went on to demonstrate the cytotoxicity of NSP11 aggregate...
Alpha-synuclein seeds in olfactory mucosa of patients with isolated REM sleep behaviour disorder (2021)
Ambra Stefani, Alex Iranzo, Evi Holzknecht, Daniela Perra, Matilde Bongianni, Carles Gaig, Beatrice Heim, Monica Serradell, Luca Sacchetto, Alicia Garrido, Stefano Capaldi, Almudena Sánchez-Gómez, Maria Paola Cecchini, Sara Mariotto, Sergio Ferrari, Michele Fiorini, Joachim Schmutzhard, Pietro Cocchiara, Isabel Vilaseca, Lorenzo Brozzetti, Salvatore Monaco, M Jose Marti, Klaus Seppi, Eduardo Tolosa, Joan Santamaria, Birgit Högl, Werner Poewe, Gianluigi Zanusso
http://dx.doi.org/10.1093/brain/awab005
Apr 07, 2023 - Over 80% of patients with isolated REM sleep behavior disorder (RBD) will subsequently convert to Parkinson’s disease, Lewy body dementia or multiple system atrophy within 10-15 years. RBD is therefore considered to be an early warning sign of neurodegenerative disease affecting th...
Anna Heidbreder, Thomas Sonnweber, Ambra Stefani, Abubaker Ibrahim, Matteo Cesari, Melanie Bergmann, Elisabeth Brandauer, Ivan Tancevski, Judith Löffler-Ragg, Birgit Högl
http://www.ncbi.nlm.nih.gov/pubmed/33588262
Apr 07, 2023 - 11 patients were evaluated for REM sleep behavior disorder (RBD) 60 days after being diagnosed with COVID-19 infection. Video polysomnograms showed evidence of REM sleep without atonia, an early sign of RBD, in 4 of these patients. A separate case-control study, REM sleep without a...
A case series of cutaneous phosphorylated α-synuclein in Long-COVID POTS (2022)
Mitchell G. Miglis, Jordan Seliger, Ruba Shaik, Christopher H. Gibbons
http://www.ncbi.nlm.nih.gov/pubmed/35570247
Apr 07, 2023 - The authors demonstrate the presence of phosphorylated alpha-synuclein (p-aSyn) in the skin of 5 out of 8 patients with long covid postural orthostatic tachycardia syndrome (POTS). P-aSyn is a biomarker for synucleinopathies and was detected using an immunohistochemical method. 3 o...
Pei Huang, Lin-Yuan Zhang, Yu-Yan Tan, Sheng-Di Chen
http://www.ncbi.nlm.nih.gov/pubmed/36717892
Apr 06, 2023 - This review captures some of the big studies and meta-studies on neurodegenerative disease and PD. Bullet points include: SARS-CoV2 infection can initiate Parkinson's disease, and can also initiate transient PD-like symptoms. Mechanism is not clear but infection of neurons seems l...
http://dx.doi.org/10.46439/allergy.2.023
Mar 14, 2023 - This case report describes an instance of severe inflammatory response presenting with covid, which was managed successfully with steroids. This seems similar to "toxic shock" syndrome, usually characterised as a rare but severe inflammatory reaction to bacteria or bacter...
Long-term cardiovascular outcomes of COVID-19 (2022)
Yan Xie, Evan Xu, Benjamin Bowe, Ziyad Al-Aly
2 comments on PubPeer • http://dx.doi.org/10.1038/s41591-022-01689-3
Feb 15, 2023 - This study looks at medical records of veterans, identifying substantial cardiovascular risk over the 12 months following SARS-CoV2 infection. This study is data driven and has been leading people to look for mechanisms and pathways, clotting (perhaps driven by inflammatory process...
Maxime Taquet, Rebecca Sillett, Lena Zhu, Jacob Mendel, Isabella Camplisson, Quentin Dercon, Paul J Harrison
http://www.ncbi.nlm.nih.gov/pubmed/35987197
Feb 13, 2023 - This paper shows an increased risk of neurodegenerative and neuroinflammatory disease following COVID diagnosis. Expresssed proportionally to basline risk, the sequence is: myoneural/muscular > dementia > cognitive deficit > psychotic disorder > (Guillain-Barre and epil...
Associations between air pollution and multimorbidity in the UK Biobank: A cross-sectional study (2022)
Amy Ronaldson, Jorge Arias de la Torre, Mark Ashworth, Anna L. Hansell, Matthew Hotopf, Ian Mudway, Rob Stewart, Alex Dregan, Ioannis Bakolis
http://www.ncbi.nlm.nih.gov/pubmed/36530697
Jan 30, 2023 - "Multimorbidity" is defined as the co-existence of two or more long-term conditions such as chronic neurological or respiratory diseases. These diseases may be related to some extent, as clusters (the term "meta-syndrome" is not used but would be handy in this ...
Ling Liu, Bruce Urch, Mieczyslaw Szyszkowicz, Greg Evans, Mary Speck, Angela Van Huang, Karen Leingartner, Robin H. Shutt, Guillaume Pelletier, Diane R. Gold, Jeffrey R. Brook, Krystal Godri Pollitt, Frances S. Silverman
http://www.ncbi.nlm.nih.gov/pubmed/30420132
Nov 07, 2022 - This is a rare controlled human trial of exposure to a panel of metal particulates. Inflammatory marker responses are taken metal-by-metal, with Aluminium coming off badly. Multiple indicators of neurological stress appeared shortly after exposure, including Parkinsons-related an...
Composition of Air Pollution Particles and Oxidative Stress in Cells, Tissues, and Living Systems (2012)
Andrew J. Ghio, Martha Sue Carraway, Michael C. Madden
http://dx.doi.org/10.1080/10937404.2012.632359
Nov 07, 2022 - This is a big, foundational, review of oxidative stress biochemistry (as driven by air pollution).
John K. Kodros, Michelle L. Bell, Francesca Dominici, Christian L’Orange, Krystal J. Godri Pollitt, Scott Weichenthal, Xiao Wu, John Volckens
http://www.ncbi.nlm.nih.gov/pubmed/36319637
Nov 07, 2022 - The phenomenon of racial inequality being expressed by increased exposure to pollution appears to be exceptionally strong in relation to airborne metals pollution for some reason. Possibly because the legal and political levers for controlling such pollution are not available to u...
Ning Li, Minqi Hao, Robert F. Phalen, William C. Hinds, Andre E. Nel
http://dx.doi.org/10.1016/j.clim.2003.08.006
Nov 07, 2022 - Asthma as an inflammatory disease driven by oxidative stress. Traffic-derived particulates (diesel in particular) as the inflammatory stimulus.
A multinational Delphi consensus to end the COVID-19 public health threat (2022)
Jeffrey V. Lazarus, Diana Romero, Christopher J. Kopka, Salim Abdool Karim, Laith J. Abu-Raddad, Gisele Almeida, Ricardo Baptista-Leite, Joshua A. Barocas, Mauricio L. Barreto, Yaneer Bar-Yam, Quique Bassat, Carolina Batista, Morgan Bazilian, Shu-Ti Chiou, Carlos del Rio, Gregory J. Dore, George F. Gao, Lawrence O. Gostin, Margaret Hellard, Jose L. Jimenez, Gagandeep Kang, Nancy Lee, Mojca Matičič, Martin McKee, Sabin Nsanzimana, Miquel Oliu-Barton, Bary Pradelski, Oksana Pyzik, Kenneth Rabin, Sunil Raina, Sabina Faiz Rashid, Magdalena Rathe, Rocio Saenz, Sudhvir Singh, Malene Trock-Hempler, Sonia Villapol, Peiling Yap, Agnes Binagwaho, Adeeba Kamarulzaman, Ayman El-Mohandes, Mauricio Barreto, Carlos del Rio, Salim Abdulla, Sarah Addleman, Gulnara Aghayeva, Raymond Agius, Mohammed Ahmed, Mohamed Ahmed Ramy, Pedro Aide, Soo Aleman, Jean-Patrick Alfred, Shamim Ali, Jorge Aliaga, Tammam Aloudat, Saleh A. Alqahtani, Jameela Al-Salman, John H. Amuasi, Anurag Agrawal, Wagida Anwar, Tania Araujo-Jorge, Osvaldo Artaza, Leyla Asadi, Yaw Awuku, Michael Baker, Lorena Barberia, Ernesto Bascolo, Paul Belcher, Lizett Bell, Adele Benzaken, Emil Bergholtz, Nahid Bhadelia, Anant Bhan, Stephane Bilodeau, Ricardo Bitrán, Philomena Bluyssen, Arnold Bosman, Fernando A. Bozza, Melanie M. Brinkmann, Andrew Brown, Bruce Mellado, Elizabeth Bukusi, Chris Bullen, Giorgio Buonanno, Rochelle Burgess, Matthew Butler, Pauline Byakika-Kibwika, Baltica Cabieses, Gunilla Carlsson, Fidelia Cascini, Chishala Chabala, Mohamed Chakroun, K. K. Cheng, Agnes Chetty, Dmytro Chumachenko, Gregg Consalves, Andrew Conway Morris, Ahmed Cordie, Tumani Corrah, Brenda Crabtree-Ramírez, Naranjargal Dashdorj, Nadav Davidovitch, Luis Eugenio de Souza, Akshay Chand Dhariwal, Elena Druică, Onder Ergonul, Ngozi A. Erondu, Mohammad Yasir Essar, Andrew Ewing, Gonzalo Fanjul, Daniel Feierstein, Eric Feigl-Ding, Ramon Figueroa, John Peter Figueroa, Dale Fisher, Walter Flores, David A. Forero-Peña, Howard Frumkin, Amiran Gamkrelidze, Monica Gandhi, Patricia Garcia, Alberto L. Garcia-Basteiro, Adolfo García-Sastre, Suneela Garg, F. A. Gbeasor-Komlanvi, Carlos Gershenson, Ishwar Gilada, Ligia Giovanella, Marino González, Manfred S. Green, Trisha Greenhalgh, Paul Griffin, Stephen Griffin, Beatriz Grinsztejn, Tanu Anand, Germán Guerra, Renzo Guinto, Mariusz Gujski, Rahmet Guner, Adam Hamdy, Marian-Gabriel Hâncean, Abusayeed Haniffa, Kenneth Y. Hartigan-Go, Hoda K. Hassan, Simon I. Hay, Matti T. J. Heino, Zdenek Hel, Peter Hotez, Jia Hu, Mirsada Hukić, Carel IJsselmuiden, Davidson Iroko, Maged Iskarous, Chimaraoke Izugbara, Choolwe Jacobs, Alejandro R. Jadad, Fyezah Jehan, Ayana Jordan, Imane Jroundi, Kevin Kain, Fatjona Kamberi, Eduard Karamov, Abraar Karan, Rebecca Katz, Aris Katzourakis, Abigail Kazembe, Faryal Khamis, Komiljon Khamzayev, Judy Khanyola, Kamlesh Khunti, Elsie Kiguli-Malwadde, Woo Joo Kim, Bruce J. Kirenga, Daniel Klimovský, Brittany L. Kmush, Felicia Knaul, Manolis Kogevinas, Frederik Kristensen, Dinesh Kumar, Raman Kumar, Amanda Kvalsvig, Marcus V. Lacerda, Arush Lal, Tom Lawton, Jay Lemery, Anthony J. Leonardi, Yuguo Li, Jan Löttvall, Mohamed Lounis, Daniel Maceira, C. Raina MacIntyre, Azzeddine Madani, Gkikas Magiorkinis, Reza Malekzadeh, Marc Choisy, Jasmine R. Marcelin, Guy B. Marks, Linsey Marr, Jeanne Marrazzo, Antonieta Martina, José M. Martín-Moreno, Carlos Mateos, Mayfong Mayxay, Jean Bapiste Mazarati, Souleymane Mboup, Jennifer McDonald, Faye McMillan, Enkeleint Mechili, Andre Medici, Sarah L. M. Davis, Petra Meier, Ziad A. Memish, Jaideep Menon, Purnima Menon, Jonathan Mesiano-Crookston, Susan Michie, Ivana Mikolasevic, Ognjen Milicevic, Asit Kumar Mishra, Rahma Mohamed, Ali H. Mokdad, Michele Monroy-Valle, Lidia Morawska, Sterghios A. Moschos, Karam Motawea, Sayed Hamid Mousavi, Ghina Mumtaz, Peter K. Munene, Carmen Muñoz Almagro, Janet Muriuki, Sylvia Muyingo, Denise Naniche, C. David Naylor, Nicaise Ndembi, Juraj Nemec, Igor Nesteruk, Christine Ngaruiya, Hung Nguyen, Dafina Nikolova, Dorit Nitzan, Ole Norheim, Mohammed Noushad, Francine Ntoumi, Gunhild Alvik Nyborg, Eleanor Ochodo, Zekaver Odabasi, Mbah Patrick Okwen, Keiser Olivia, David S. Y. Ong, Ijeoma Opara, Miguel Orozco, Hitoshi Oshitani, Christina Pagel, Madhukar Pai, Björg Pálsdóttir, Georgios Papatheodoridis, Dimitrios Paraskevis, Jeanna Parsons Leigh, Bernard Pécoul, Andreas Peichl, Eddy Perez-Then, Phuc Pham Duc, Cécile Philippe, Andrea Pineda Rojas, Courtney Pladsen, Anton Pozniak, Rodrigo Quiroga, Huma Qureshi, Sanjay Rampal, Megan Ranney, Laura Rathe, Scott Ratzan, Henriette Raventos, Helen Rees, Renata Reis, Walter Ricciardi, Nesrine Rizk, Magda Robalo, Eleanor Robertson, Leanne Robinson, Casper Rokx, Tamsin Ros, John-Arne Røttingen, Meir Rubin, Kiat Ruxrungtam, Shakhlo Sadirova, Senjuti Saha, Nelly Salgado, Lizet Sanchez, Thurka Sangaramoorthy, Carolina Santamaria-Ulloa, Renata Santos, Bisher Sawaf, Matthias F. Schneider, Robert T. Schooley, Alper Sener, Jaime Sepulveda, Jaffer Shah, Mosa Shibani, Sheikh Shoib, Izukanji Sikazwe, Aistis Šimaitis, Amandeep Singh Gill, Natia Skhvitaridze, Milka Sokolović, Roma Solomon, Xavier Solórzano, Sandra A. Springer, Jakub Šrol, Anthony Staines, Henry T. Stelfox, Steffanie Strathdee, Lokman Hakim Sulaiman, Brett Sutton, Dag Svanæs, Sarya Swed, Vana Sypsa, Kristine Sørensen, Raji Tajudeen, Amy Tan, Julian Tang, Marcel Tanner, Tavpritesh Sethi, Marleen Temmerman, Kyu Kyu Than, Halidou Tinto, Sênoudé Pacôme Tomètissi, Irene Torres, K. P. Tshering, Sotirios Tsiodras, Benjamin Tsofa, Anders Vahlne, Juan Rafael Vargas, Ivan Dario Velez Bernal, Deisy Ventura, Rafael Vilasanjuan, Joe Vipond, Sarah Wamala-Andersson, Pawel Wargocki, Robert West, Angela Weyand, Trenton M. White, Guntram Wolff, Maosheng Yao, Christian A. Yates, Georgina Yeboah, Leo Yee-Sin, Siyan Yi, Yik-Ying Teo, Poovorawan Yong, Victor Zamora-Mesía, Anne Øvrehus
3 comments on PubPeer • http://www.ncbi.nlm.nih.gov/pubmed/36329272
Nov 07, 2022 - "What To Do About Covid?" This massive survey of scientists, doctors and other experts agrees on many actions to take. Most countries with means are already acting on most points, but an important one which is often overlooked is to improve air quality inside buildings: ...
Yadi Zhou, Yuan Liu, Shagun Gupta, Mauricio I. Paramo, Yuan Hou, Chengsheng Mao, Yuan Luo, Julius Judd, Shayne Wierbowski, Marta Bertolotti, Mriganka Nerkar, Lara Jehi, Nir Drayman, Vlad Nicolaescu, Haley Gula, Savaş Tay, Glenn Randall, Peihui Wang, John T. Lis, Cédric Feschotte, Serpil C. Erzurum, Feixiong Cheng, Haiyuan Yu
3 comments on PubPeer • http://www.ncbi.nlm.nih.gov/pubmed/36217030
Nov 07, 2022 - This COVID interactome shows the (hypothetically) amyloidogenic peptides ORF6 and ORF10 as sharing a large number of host interaction partners. What do all these targets do? Just now I have no idea, but the commonality of ORF6 and ORF10 is very interesting.
Lilian Calderón-Garcidueñas, Angélica González-Maciel, Rafael Reynoso-Robles, Jessica Hammond, Randy Kulesza, Ingolf Lachmann, Ricardo Torres-Jardón, Partha S. Mukherjee, Barbara A. Maher
http://dx.doi.org/10.1016/j.envres.2020.110139
Oct 06, 2022 - Air pollution (in particular metallic nanoparticles) linked to early-onset neurodegenerative disease by autopsy studies. Metallic nanoparticles are abundant in Luxembourg and well documented (steel recycling plants in otherwise residential areas), so this could be good starting po...
The Contribution of Microglia to Neuroinflammation in Parkinson's Disease (2021)
Katja Badanjak, Sonja Fixemer, Semra Smajić, Alexander Skupin, Anne Grünewald
http://www.ncbi.nlm.nih.gov/pubmed/33925154
Oct 04, 2022 - Review discussing the role of microglia in relation to neuroinflammation and Parkinson's.
Pierre Garcia, Wiebke Jürgens‐Wemheuer, Oihane Uriarte Huarte, Alessandro Michelucci, Annette Masuch, Simone Brioschi, Andreas Weihofen, Eric Koncina, Djalil Coowar, Tony Heurtaux, Enrico Glaab, Rudi Balling, Carole Sousa, Tony Kaoma, Nathalie Nicot, Tatjana Pfander, Walter Schulz‐Schaeffer, Ahmad Allouche, Nicolas Fischer, Knut Biber, Felix Kleine‐Borgmann, Michel Mittelbronn, Marek Ostaszewski, Kristopher J. Schmit, Manuel Buttini
http://www.ncbi.nlm.nih.gov/pubmed/35092321
Oct 04, 2022 - Neuroinflammation precedes neurodegeneration in a mouse model of Parkinson's disease.
Bowen Li, Ling Mo, Yuhui Yang, Shuai Zhang, Jingbing Xu, Yueting Ge, Yuncong Xu, Yonghui Shi, Guowei Le
http://www.ncbi.nlm.nih.gov/pubmed/35519476
Oct 04, 2022 - Protein oxidation products are an immediate downstream consequence of inflammatory stimuli. Here it is shown that ingestion of oxidation-damaged peptides can cause neurological harm to rats.
Julie-Myrtille Bourgognon, Jereme G. Spiers, Sue W. Robinson, Hannah Scheiblich, Paul Glynn, Catharine Ortori, Sophie J. Bradley, Andrew B. Tobin, Joern R. Steinert
http://www.ncbi.nlm.nih.gov/pubmed/33653950
Oct 04, 2022 - This work establishes that inflammatory phenomena are a necessary precursor to (a mouse model of) neurodegenerative amyloid disease.
Mirren Charnley, Saba Islam, Guneet K. Bindra, Jeremy Engwirda, Julian Ratcliffe, Jiangtao Zhou, Raffaele Mezzenga, Mark D. Hulett, Kyunghoon Han, Joshua T. Berryman, Nicholas P. Reynolds
4 comments on PubPeer • http://www.ncbi.nlm.nih.gov/pubmed/35697699
Oct 04, 2022 - Short peptide fragments from the SARS-CoV-2 genome were examined in vitro, in silico, and in cells. The fragments were found to be prone to amyloid self-assembly, and to be neurotoxic. It is not clear what function this serves to the virus, if any, however SARS-CoV-2 is unusual i...
