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Updated Apr 30, 2025 108 subscribers

Synthetic Organic Chemistry

A curated collection of highlights from the synthetic organic chemistry literature.

Editor Timothy Kwok

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This Peeriodical is intended for an audience that wants to learn as broadly—and as efficiently—as possible about the synthetic chemistry literature. 

Featured papers are selected not only on the basis of scientific merit, but also of the clarity with which they convey their learning points. Thus, there is a heavier emphasis on reviews and tutorial-style guides, particularly well-written ones.

Published

Exceptions, Paradoxes, and Their Resolutions in Chemical Reactivity (2024)

Guanqi Qiu

http://www.ncbi.nlm.nih.gov/pubmed/39506459

Apr 30, 2025

Practical Considerations in Kinetic Resolution Reactions (2001)

John M. Keith, Jay F. Larrow, Eric N. Jacobsen

https://doi.org/10.1002/1615-4169(20010129)343:1<5::aid-adsc5>3.0.co;2-i

Mar 30, 2025

Observation and Characterization of Single Elementary Reactions of Organometallics (2024)

Konrad Koszinowski

https://doi.org/10.1021/acs.organomet.3c00415

Jan 31, 2025

A Matter of Life(time) and Death (2018)

http://dx.doi.org/10.1021/acscatal.8b03199

Dec 31, 2024

Distinctive Reaction Pathways at Base Metals in High-Spin Organometallic Catalysts (2015)

Patrick L. Holland

https://doi.org/10.1021/acs.accounts.5b00036

Dec 21, 2024

Effects of filled .pi. and unfilled .sigma. molecular orbital interactions on molecular structure (1977)

William Cherry, Nicholas Epiotis, Weston Thatcher Borden

http://dx.doi.org/10.1021/ar50113a003

Oct 30, 2024

The advent and development of organocatalysis (2008)

David W. C. MacMillan

http://www.ncbi.nlm.nih.gov/pubmed/18800128

Sep 30, 2024

Azide rearrangements in electron-deficient systems (2006)

S. Lang, J. A. Murphy

http://dx.doi.org/10.1039/b505080d

Aug 31, 2024

Organic Synthesis Away from Equilibrium: Contrathermodynamic Transformations Enabled by Excited-State Electron Transfer (2024)

Angela Lin, Sumin Lee, Robert R. Knowles

http://dx.doi.org/10.1021/acs.accounts.4c00227

Aug 15, 2024

High‐valent bismuth redox catalysis (2021)

Oriol Planas, Josep Cornella

http://dx.doi.org/10.1002/nadc.20214116551

Aug 03, 2024

An overview of N-heterocyclic carbenes (2014)

Matthew N. Hopkinson, Christian Richter, Michael Schedler, Frank Glorius

http://dx.doi.org/10.1038/nature13384

Jul 19, 2024

Viedma ripening: a reliable crystallisation method to reach single chirality (2015)

Leyla-Cann Sögütoglu, René R. E. Steendam, Hugo Meekes, Elias Vlieg, Floris P. J. T. Rutjes

http://dx.doi.org/10.1039/c5cs00196j

Jul 13, 2024

Lithiation–Borylation Methodology and Its Application in Synthesis (2014)

Daniele Leonori, Varinder K. Aggarwal

http://dx.doi.org/10.1021/ar5002473

Jul 08, 2024

Theoretical aspects of palladium-catalysed carbon–carbon cross-coupling reactions (2010)

Liqin Xue, Zhenyang Lin

http://dx.doi.org/10.1039/b814973a

Jul 04, 2024

Disproportional inflation of clinical trial costs: why we should care, and what we should do about it (2024)

Hemme J. Hijma, Ahnjili Zhuparris, Ewoud-Jan van Hoogdalem, Adam F. Cohen

http://dx.doi.org/10.1038/d41573-024-00002-w

Jun 21, 2024

Dynamic Thermodynamic Resolution:  Control of Enantioselectivity through Diastereomeric Equilibration (2000)

Peter Beak, David R. Anderson, Michael D. Curtis, Jason M. Laumer, Daniel J. Pippel, Gerald A. Weisenburger

http://dx.doi.org/10.1021/ar000077s

Jun 11, 2024

Leveraging the Redox Promiscuity of Nickel To Catalyze C–N Coupling Reactions (2024)

Olivia R. Taylor, Paul J. Saucedo, Ana Bahamonde

http://dx.doi.org/10.1021/acs.joc.3c02353

Jun 01, 2024

Palladium (II)‐Catalyzed C–H Activation with Bifunctional Ligands: From Curiosity to Industrialization (2024)

Kevin Wu, Nelson Lam, Daniel A. Strassfeld, Zhoulong Fan, Jennifer X. Qiao, Tao Liu, Dean Stamos, Jin-Quan Yu

http://dx.doi.org/10.1002/anie.202400509

May 17, 2024

Adaptive Partial Drug Approval: A Health Policy Proposal (2009)

Charles F Manski

http://dx.doi.org/10.2202/1553-3832.1449

May 06, 2024

Cooperative Hydrogen Atom Transfer: From Theory to Applications (2021)

Julian G. West, Padmanabha V. Kattamuri

http://dx.doi.org/10.1055/a-1463-9527

Apr 27, 2024

Application of the Spin-Center Shift in Organic Synthesis (2022)

Feng-Lian Zhang, Bin Li, K. N. Houk, Yi-Feng Wang

http://dx.doi.org/10.1021/jacsau.2c00051

Apr 21, 2024

A General Model for Selectivity in Olefin Cross Metathesis (2003)

Arnab K. Chatterjee, Tae-Lim Choi, Daniel P. Sanders, Robert H. Grubbs

http://dx.doi.org/10.1021/ja0214882

Apr 16, 2024

Innovation in the pharmaceutical industry (2000)

David F Horrobin

http://dx.doi.org/10.1177/014107680009300702

Apr 11, 2024

Asymmetric Catalysis in Radical Chemistry (2022)

David A. Nagib

http://dx.doi.org/10.1021/acs.chemrev.2c00622

Apr 06, 2024

Do the Terms “% ee” and “% de” Make Sense as Expressions of Stereoisomer Composition or Stereoselectivity? (2006)

Robert E. Gawley

http://dx.doi.org/10.1021/jo052554w

Mar 31, 2024

Towards Perfect Asymmetric Catalysis: Additives and Cocatalysts (1999)

Erasmus M. Vogl, Harald Gröger, Masakatsu Shibasaki

http://dx.doi.org/10.1002/(sici)1521-3773(19990601)38:11<1570::aid-anie1570>3.0.co;2-y

Mar 21, 2024

Halogen dance reactions—A review (2007)

Michael Schnürch, Markus Spina, Ather Farooq Khan, Marko D. Mihovilovic, Peter Stanetty

http://dx.doi.org/10.1039/b607701n

Mar 15, 2024

σ-Bond Metathesis: A 30-Year Retrospective (2013)

Rory Waterman

http://dx.doi.org/10.1021/om400760k

Mar 05, 2024

Economics of the Pharmaceutical Industry (2018)

Darius N. Lakdawalla

http://dx.doi.org/10.1257/jel.20161327

Feb 28, 2024

Application of pulsed electrolysis in organic electrosynthesis (2024)

Alexander P. Atkins, Alastair J.J. Lennox

http://dx.doi.org/10.1016/j.coelec.2024.101441

Feb 22, 2024

Restoring the pharmaceutical industry's reputation (2014)

Mark Kessel

http://dx.doi.org/10.1038/nbt.3036

Feb 20, 2024

Copper catalysed Ullmann type chemistry: from mechanistic aspects to modern development (2014)

Carlo Sambiagio, Stephen P. Marsden, A. John Blacker, Patrick C. McGowan

http://dx.doi.org/10.1039/c3cs60289c

Feb 13, 2024

Breaking Eroom's Law (2020)

Michael S. Ringel, Jack W. Scannell, Mathias Baedeker, Ulrik Schulze

http://www.ncbi.nlm.nih.gov/pubmed/32300238

Jan 08, 2024

“If Pigs Could Fly” Chemistry: A Tutorial on the Principle of Microscopic Reversibility (2009)

Donna G. Blackmond

http://dx.doi.org/10.1002/anie.200804566

Dec 30, 2023

Realism in drug discovery—could Cassandra be right? (2001)

David F. Horrobin

http://dx.doi.org/10.1038/nbt1201-1099

Dec 24, 2023

Drug research: myths, hype and reality (2003)

Hugo Kubinyi

http://dx.doi.org/10.1038/nrd1156

Dec 19, 2023

Non-Sequential Processes for the Transformation of a Racemate into a Single Stereoisomeric Product: Proposal for Stereochemical Classification (2001)

Kurt Faber

http://dx.doi.org/10.1002/1521-3765(20011203)7:23<5004::aid-chem5004>3.0.co;2-x

Dec 13, 2023

Adapting to the Changing Landscape of Biotech-Driven Drug Discovery (2023)

Dean G. Brown

http://dx.doi.org/10.1021/acs.jmedchem.3c02035

Dec 05, 2023

The six-bond bound (2007)

Gernot Frenking, Ralf Tonner

http://dx.doi.org/10.1038/446276a

Nov 26, 2023

The Interplay of Theory and Experiment in the Study of Phenylnitrene (2000)

Weston Thatcher Borden, Nina P. Gritsan, Christopher M. Hadad, William L. Karney, Carl R. Kemnitz, Matthew S. Platz

http://dx.doi.org/10.1021/ar990030a

Nov 21, 2023

Diagnosing the decline in pharmaceutical R&D efficiency (2012)

Jack W. Scannell, Alex Blanckley, Helen Boldon, Brian Warrington

http://dx.doi.org/10.1038/nrd3681

Nov 16, 2023

Development of Palladium Precatalysts that Efficiently Generate LPd(0) Active Species (2020)

Kevin H. Shaughnessy

http://dx.doi.org/10.1002/ijch.201900067

Nov 12, 2023

Oxidation and Reduction Reactions in Organic Chemistry (2010)

Ivan A. Shibley, Katie E. Amaral, David J. Aurentz, Ronald J. McCaully

http://dx.doi.org/10.1021/ed100457z

Nov 05, 2023

Tandem catalysis: a taxonomy and illustrative review (2004)

Deryn E. Fogg, Eduardo N. dos Santos

http://dx.doi.org/10.1016/j.ccr.2004.05.012

Oct 31, 2023

Peptide-Based Catalysts Reach the Outer Sphere through Remote Desymmetrization and Atroposelectivity (2019)

Anthony J. Metrano, Scott J. Miller

http://www.ncbi.nlm.nih.gov/pubmed/30525436

Oct 26, 2023

Why is it hard to terminate failing projects in pharmaceutical R&D? (2015)

Richard W. Peck, Dennis W. Lendrem, Iain Grant, B. Clare Lendrem, John D. Isaacs

http://dx.doi.org/10.1038/nrd4725

Oct 16, 2023

Evolving Outsourcing Landscape in Pharma R&D: Different Collaborative Models and Factors To Consider When Choosing a Contract Research Organization (2020)

Bart L. DeCorte

http://dx.doi.org/10.1021/acs.jmedchem.0c00176

Oct 10, 2023

Dehydrogenation as a Substrate-Activating Strategy in Homogeneous Transition-Metal Catalysis (2010)

Graham E. Dobereiner, Robert H. Crabtree

http://dx.doi.org/10.1021/cr900202j

Oct 05, 2023

Mechanisms of Nickel-Catalyzed Cross-Coupling Reactions (2019)

Justin B. Diccianni, Tianning Diao

http://dx.doi.org/10.1016/j.trechm.2019.08.004

Sep 29, 2023

What does it mean that “something is green”? The fundamentals of a Unified Greenness Theory (2023)

Paweł Mateusz Nowak

http://dx.doi.org/10.1039/d3gc00800b

Sep 20, 2023

How to Develop Organometallic Catalytic Reactions in the Pharmaceutical Industry (2023)

Vittorio Farina

http://dx.doi.org/10.1021/acs.oprd.3c00086

Sep 15, 2023

Discovery and Development of the Enantioselective Minisci Reaction (2023)

P. David Bacoş, Antti S. K. Lahdenperä, Robert J. Phipps

http://dx.doi.org/10.1021/acs.accounts.3c00247

Sep 10, 2023

Redox catalysis in organic electrosynthesis: basic principles and recent developments (2014)

Robert Francke, R. Daniel Little

http://dx.doi.org/10.1039/c3cs60464k

Sep 04, 2023

Catalytic, Stereoselective Dihalogenation of Alkenes: Challenges and Opportunities (2015)

Alexander J. Cresswell, Stanley T.‐C. Eey, Scott E. Denmark

http://dx.doi.org/10.1002/anie.201507152

Aug 30, 2023

Stereospecific nucleophilic substitution at tertiary and quaternary stereocentres (2020)

Ilan Marek, Veeranjaneyulu Lanke

http://dx.doi.org/10.1039/d0sc02562c

Aug 14, 2023

The High Chemofidelity of Metal-Catalyzed Hydrogen Atom Transfer (2018)

Samantha A. Green, Steven W. M. Crossley, Jeishla L. M. Matos, Suhelen Vásquez-Céspedes, Sophia L. Shevick, Ryan A. Shenvi

http://dx.doi.org/10.1021/acs.accounts.8b00337

Aug 07, 2023

Carbon–Heteroatom Coupling Using Pd-PEPPSI Complexes (2014)

Cory Valente, Matthew Pompeo, Mahmoud Sayah, Michael G. Organ

http://dx.doi.org/10.1021/op400278d

Aug 01, 2023

Synthetic half-reactions (2020)

Andrei K. Yudin

http://dx.doi.org/10.1039/d0sc03876h

Jul 24, 2023

Parallel Kinetic Resolutions (2000)

Jason Eames

http://dx.doi.org/10.1002/(sici)1521-3773(20000303)39:5<885::aid-anie885>3.0.co;2-2

Jul 18, 2023

Electrode Materials in Modern Organic Electrochemistry (2020)

David M Heard, Alastair J J Lennox

http://www.ncbi.nlm.nih.gov/pubmed/32633073

Jul 14, 2023

Catalytic Deracemization Reactions (2023)

Mouxin Huang, Tianrun Pan, Xieyang Jiang, Sanzhong Luo

http://dx.doi.org/10.1021/jacs.3c02622

Jul 09, 2023

Catalytic Isofunctional Reactions—Expanding the Repertoire of Shuttle and Metathesis Reactions (2019)

Benjamin N. Bhawal, Bill Morandi

http://dx.doi.org/10.1002/anie.201803797

Jul 04, 2023

Thesyn/anti-Dichotomy in the Palladium-Catalyzed Addition of Nucleophiles to Alkenes (2015)

Pavel Kočovský, Jan-E. Bäckvall

http://dx.doi.org/10.1002/chem.201404070

Jun 29, 2023

Pyrylium Salts: Selective Reagents for the Activation of Primary Amino Groups in Organic Synthesis (2020)

Yue Pang, Daniel Moser, Josep Cornella

http://dx.doi.org/10.1055/s-0039-1690703

Jun 20, 2023

Mechanism-Driven Development of Group 10 Metal-Catalyzed Decarbonylative Coupling Reactions (2022)

Naish Lalloo, Conor E. Brigham, Melanie S. Sanford

http://www.ncbi.nlm.nih.gov/pubmed/36382937

Jun 13, 2023

Photophysics and photochemistry with Earth-abundant metals – fundamentals and concepts (2020)

Christoph Förster, Katja Heinze

http://dx.doi.org/10.1039/c9cs00573k

Jun 07, 2023

Charge‐Transfer and Spin‐Flip States: Thriving as Complements (2023)

Winald R. Kitzmann, Katja Heinze

http://dx.doi.org/10.1002/anie.202213207

Jun 02, 2023

Nucleophilic Substitution (S 2): Dependence on Nucleophile, Leaving Group, Central Atom, Substituents, and Solvent (2018)

Trevor A. Hamlin, Marcel Swart, F. Matthias Bickelhaupt

http://www.ncbi.nlm.nih.gov/pubmed/29542853

May 27, 2023

The Evolution of Data-Driven Modeling in Organic Chemistry (2021)

Wendy L. Williams, Lingyu Zeng, Tobias Gensch, Matthew S. Sigman, Abigail G. Doyle, Eric V. Anslyn

http://dx.doi.org/10.1021/acscentsci.1c00535

May 21, 2023

The Ascent of Alkyne Metathesis to Strategy-Level Status (2021)

Alois Fürstner

http://dx.doi.org/10.1021/jacs.1c08040

May 16, 2023

The Stille Reaction, 38 Years Later (2015)

Carlos Cordovilla, Camino Bartolomé, Jesús M Martínez-Ilarduya, Pablo Espinet

http://dx.doi.org/10.1021/acscatal.5b00448

May 11, 2023

Selection of boron reagents for Suzuki–Miyaura coupling (2014)

Alastair J. J. Lennox, Guy C. Lloyd-Jones

http://dx.doi.org/10.1039/c3cs60197h

May 06, 2023

Synthetic chemistry in a water world. New rules ripe for discovery (2018)

Bruce H. Lipshutz

http://dx.doi.org/10.1016/j.cogsc.2017.10.004

Apr 29, 2023

Machine learning the ropes: principles, applications and directions in synthetic chemistry (2020)

Felix Strieth-Kalthoff, Frederik Sandfort, Marwin H. S. Segler, Frank Glorius

http://www.ncbi.nlm.nih.gov/pubmed/32672294

Apr 23, 2023

Stereospecific and stereoconvergent nucleophilic substitution reactions at tertiary carbon centers (2021)

Xin Zhang, Choon-Hong Tan

http://dx.doi.org/10.1016/j.chempr.2020.11.022

Apr 16, 2023

Implementation of High Throughput Experimentation across Medicinal Chemistry, Process Chemistry and Materials Science (2022)

C. Liana Allen, Kelsey F. VanGelder, Courtney K. Maguire

http://dx.doi.org/10.1021/bk-2022-1419.ch003

Apr 12, 2023

Bismuth(V)-Mediated C–H Arylation of Phenols and Naphthols (2021)

Liam T. Ball, Aaron Senior

http://dx.doi.org/10.1055/s-0040-1706294

Apr 05, 2023

The photophysics of photoredox catalysis: a roadmap for catalyst design (2016)

Daniela M. Arias-Rotondo, James K. McCusker

http://dx.doi.org/10.1039/c6cs00526h

Mar 28, 2023

Nickel and Palladium Catalysis: Stronger Demand than Ever (2022)

Victor M. Chernyshev, Valentine P. Ananikov

http://dx.doi.org/10.1021/acscatal.1c04705

Mar 23, 2023

Large-Scale Amidations in Process Chemistry: Practical Considerations for Reagent Selection and Reaction Execution (2022)

Javier Magano

http://dx.doi.org/10.1021/acs.oprd.2c00005

Mar 16, 2023

Single-atom logic for heterocycle editing (2022)

Justin Jurczyk, Jisoo Woo, Sojung F. Kim, Balu D. Dherange, Richmond Sarpong, Mark D. Levin

http://www.ncbi.nlm.nih.gov/pubmed/35935106

Mar 12, 2023

Methods and Mechanisms for Cross-Electrophile Coupling of Csp(2) Halides with Alkyl Electrophiles (2015)

Daniel J. Weix

http://www.ncbi.nlm.nih.gov/pubmed/26011466

Feb 28, 2023

Biaryl Monophosphine Ligands in Palladium-Catalyzed C-N Coupling: An Updated User's Guide (2019)

Bryan T. Ingoglia, Corin C. Wagen, Stephen L. Buchwald

http://www.ncbi.nlm.nih.gov/pubmed/31896889

Feb 22, 2023

Bicyclobutanes as unusual building blocks for complexity generation in organic synthesis (2023)

Maxim Golfmann, Johannes C. L. Walker

http://dx.doi.org/10.1038/s42004-022-00811-3

Feb 13, 2023

Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion (2016)

Alois Fürstner

http://www.ncbi.nlm.nih.gov/pubmed/27981231

Feb 10, 2023

Well-defined nickel and palladium precatalysts for cross-coupling (2017)

Nilay Hazari, Patrick R. Melvin, Megan Mohadjer Beromi

http://dx.doi.org/10.1038/s41570-017-0025

Jan 31, 2023

Predictive chemistry: machine learning for reaction deployment, reaction development, and reaction discovery (2023)

Zhengkai Tu, Thijs Stuyver, Connor W. Coley

http://dx.doi.org/10.1039/d2sc05089g

Jan 25, 2023

The interplay of polar effects in controlling the selectivity of radical reactions (2022)

Alessandro Ruffoni, Rory C. Mykura, Massimo Bietti, Daniele Leonori

http://dx.doi.org/10.1038/s44160-022-00108-2

Jan 19, 2023

A Perspective on the Analytical Challenges Encountered in High-Throughput Experimentation (2021)

Rachel Grainger, Stuart Whibley

http://dx.doi.org/10.1021/acs.oprd.0c00463

Jan 11, 2023

Photons as a 21st century reagent (2020)

Holly E. Bonfield, Thomas Knauber, François Lévesque, Eric G. Moschetta, Flavien Susanne, Lee J. Edwards

http://dx.doi.org/10.1038/s41467-019-13988-4

Jan 07, 2023 - Lists several pieces of key experimental information for photochemical reactions that authors often leave out in the Experimental section of papers; the review also discusses why knowing this experimental information is critical for reproducing the reaction.

Six Impossible Mechanisms Before Breakfast: Arrow Pushing as an Instructional Device in Inorganic Chemistry (2013)

Steffen Berg, Abhik Ghosh

http://dx.doi.org/10.1021/ed3006693

Jan 04, 2023

Valence, Oxidation Number, and Formal Charge: Three Related but Fundamentally Different Concepts (2006)

Gerard Parkin

http://dx.doi.org/10.1021/ed083p791

Jan 02, 2023

Conformational analysis of cycloalkanes (2015)

Veljko Dragojlovic

http://dx.doi.org/10.1007/s40828-015-0014-0

Dec 31, 2022

The Baldwin rules: revised and extended (2016)

Kerry Gilmore, Rana K. Mohamed, Igor V. Alabugin

http://dx.doi.org/10.1002/wcms.1261

Dec 26, 2022

Unique Atoms and the Identification of the Symmetry Elements of Molecules (2011)

John P. Graham

http://dx.doi.org/10.1021/ed1011508

Dec 24, 2022

Ring-Closing Metathesis in Pharmaceutical Development: Fundamentals, Applications, and Future Directions (2018)

Miao Yu, Sha Lou, Francisco Gonzalez-Bobes

http://dx.doi.org/10.1021/acs.oprd.8b00093

Dec 23, 2022

Facile C–F Bond Formation through a Concerted Nucleophilic Aromatic Substitution Mediated by the PhenoFluor Reagent (2017)

Constanze N. Neumann, Tobias Ritter

http://dx.doi.org/10.1021/acs.accounts.7b00413

Dec 21, 2022

Hypervalency, secondary bonding and hydrogen bonding: siblings under the skin (2017)

Robert H. Crabtree

http://dx.doi.org/10.1039/c6cs00688d

Dec 20, 2022

Tetramethylpiperidine N-Oxyl (TEMPO), Phthalimide N-Oxyl (PINO), and Related N-Oxyl Species: Electrochemical Properties and Their Use in Electrocatalytic Reactions (2018)

Jordan E. Nutting, Mohammad Rafiee, Shannon S. Stahl

http://www.ncbi.nlm.nih.gov/pubmed/29707945

Dec 11, 2022

High-Throughput Experimentation for Medicinal Chemistry: State of the Art, Challenges, and Opportunities (2022)

Dipannita Kalyani, Mycah Uehling, Michael Wleklinski

http://dx.doi.org/10.1021/bk-2022-1420.ch003

Nov 19, 2022

Different Strategies for Designing Dual-Catalytic Enantioselective Processes: From Fully Cooperative to Non-cooperative Systems (2019)

Filippo Romiti, Juan del Pozo, Paulo H. S. Paioti, Stella A. Gonsales, Xinghan Li, Felix W. W. Hartrampf, Amir H. Hoveyda

http://www.ncbi.nlm.nih.gov/pubmed/31674773

Nov 08, 2022

The electron is a catalyst (2014)

Armido Studer, Dennis P. Curran

http://dx.doi.org/10.1038/nchem.2031

Nov 01, 2022

Quasienantiomers and quasiracemates: new tools for identification, analysis, separation, and synthesis of enantiomers (2005)

Qisheng Zhang, Dennis P. Curran

http://www.ncbi.nlm.nih.gov/pubmed/15915521

Oct 30, 2022

Recognizing pitfalls in virtual screening: a critical review (2012)

Thomas Scior, Andreas Bender, Gary Tresadern, José L. Medina-Franco, Karina Martínez-Mayorga, Thierry Langer, Karina Cuanalo-Contreras, Dimitris K. Agrafiotis

http://www.ncbi.nlm.nih.gov/pubmed/22435959

Oct 29, 2022

Automation isn't automatic (2021)

Melodie Christensen, Lars P. E. Yunker, Parisa Shiri, Tara Zepel, Paloma L. Prieto, Shad Grunert, Finn Bork, Jason E. Hein

http://www.ncbi.nlm.nih.gov/pubmed/35003576

Oct 26, 2022

Rational Design of Bioinspired Catalysts for Selective Oxidations (2020)

Laia Vicens, Giorgio Olivo, Miquel Costas

http://dx.doi.org/10.1021/acscatal.0c02073

Oct 25, 2022

Unconventional Aromaticity in Organometallics: The Power of Transition Metals (2019)

Dandan Chen, Qiong Xie, Jun Zhu

http://dx.doi.org/10.1021/acs.accounts.9b00092

Oct 16, 2022

Strategies That Utilize Ion Pairing Interactions to Exert Selectivity Control in the Functionalization of C-H Bonds (2022)

James E. Gillespie, Alexander Fanourakis, Robert J. Phipps

http://www.ncbi.nlm.nih.gov/pubmed/36178308

Oct 14, 2022

A review of the problem of distinguishing true homogeneous catalysis from soluble or other metal-particle heterogeneous catalysis under reducing conditions (2003)

Jason A. Widegren, Richard G. Finke

http://dx.doi.org/10.1016/s1381-1169(02)00728-8

Oct 09, 2022

Electrochemical Oxidation of Organic Molecules at Lower Overpotential: Accessing Broader Functional Group Compatibility with Electron−Proton Transfer Mediators (2020)

Fei Wang, Shannon S. Stahl

http://dx.doi.org/10.1021/acs.accounts.9b00544

Oct 03, 2022

Mechanisms of Nickel-Catalyzed Coupling Reactions and Applications in Alkene Functionalization (2020)

Justin Diccianni, Qiao Lin, Tianning Diao

http://www.ncbi.nlm.nih.gov/pubmed/32237734

Oct 02, 2022

New Twists in Nazarov Cyclization Chemistry (2020)

Alison J. Frontier, Jackson J. Hernandez

http://dx.doi.org/10.1021/acs.accounts.0c00284

Oct 01, 2022

Counter Electrode Reactions—Important Stumbling Blocks on the Way to a Working Electro‐organic Synthesis (2022)

Martin Klein, Siegfried R. Waldvogel

http://dx.doi.org/10.1002/anie.202204140

Jul 02, 2022

Is There a Need to Discuss Atomic Orbital Overlap When Teaching Hydrogen–Halide Bond Strength and Acidity Trends in Organic Chemistry? (2015)

Deepa Devarajan, Samantha J. Gustafson, F. Matthias Bickelhaupt, Daniel H. Ess

http://dx.doi.org/10.1021/ed5005905

May 25, 2022

Process Chemistry:  The Science, Business, Logic, and Logistics (2006)

Tony Y. Zhang

http://www.ncbi.nlm.nih.gov/pubmed/16836293

May 15, 2022

Do Secondary Orbital Interactions Really Exist? (2000)

José I. García, José A. Mayoral, Luis Salvatella

http://www.ncbi.nlm.nih.gov/pubmed/11041829

May 14, 2022

Upconversion of Reductants (2019)

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